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Malaria (available outside the U.S. only)

PIFA Malaria Rapid Assay

Malaria

PIFA Malaria® is a single-use, disposable device that detects the presence of malaria antigens in blood samples by means of a whole blood filter. The device provides comparable accuracy to thick smear test methods, can use either serum or whole blood samples, and requires no capital equipment. It is an excellent option to provide quick screening for malaria in areas with high disease prevalence, even where there is relatively little medical infrastructure available.

FAST AND EASY

  • Results in only about 5 minutes!
  • Easy to use (no training necessary)
  • Easy to read results via color change

ACCURATE

  • Accuracy comparable to thick smear test method
  • Manufactured in a Current Good Manufacturing Practice (CGMP) environment

PERFECT FOR A WIDE VARIETY OF SETTINGS

  • Uses serum or whole blood samples
  • No capital equipment required

Specifications

The PIFA Malaria® rapid test is based upon the patented Particulate ImmunoFiltration Assay (PIFA®) technology. Dyed microparticles coated with antibody to P. falciparum antigens provide the visual signal for the results of the assay; the ability of agglutinated or nonagglutinated particles to move through a filter medium is the measure of the positive/negative reactivity of the test sample.

A double-blind study was conducted to compare the PIFA test to the thick smear method of detecting P. falciparum infection (n=103).  Based on this study, the PIFA test for malaria demonstrated:

  • Accuracy comparable to thick smears
  • Sensitivity = 100%
  • Specificity = 97.3%
Thick Smear Method
    Reactive Non-Reactive
PIFA®  Reactive 25 2
Non-Reactive 0 76

About Malaria

According to estimates released in December 2014, there were about 198 million cases of malaria in 2013 and an estimated 584,000 deaths.1 It is estimated that 3.4 billion people (approximately half of the world’s population) and 106 countries and territories are at risk of malaria transmission. Hundreds of millions of people live in areas where malaria is prevalent (principally in Africa, Latin America, and Asia).

Malaria is transmitted when infected female anopheline mosquitoes inject sporozoites while taking a blood meal, or when infected erythrocytes are injected intravenously. Within minutes of entering the circulation, sporozoites invade hepatocyles, where they develop as hepatic exoerythrocytic forms. There are numerous Plasmodium species but only four are important human pathogens:

  • Plasmodium falciparum
  • Plasmodium vivax
  • Plasmodium malariae
  • Plasmodium ovale

Symptoms of malaria include fever, headache, and vomiting, and usually appear between 10 and 15 days after the mosquito bite. If not treated, malaria can quickly become life-threatening by disrupting the blood supply to vital organs.

Key interventions to control malaria include prevention (i.e. use of insecticidal nets by people at risk; and indoor residual spraying with insecticide to control the vector mosquitoes), and prompt and effective treatment for those infected.2

References:
1 The World Health Organization, malaria facts (http://www.who.int/mediacentre/factsheets/fs094/en/ accessed July 8, 2015).
2 The World Health Organization, health topics – malaria, (http://www.who.int/topics/malaria/en/ accessed July 8, 2015).

How to Order

PIFA Malaria is sold as a kit containing 25 tests and related test materials as follows:

  • 25 PIFA Malaria “MiniReactor” devices, each containing a crushable ampoule of dyed microparticles, a crushable ampoule of enhancer reagent both preserved with 0.01% Sodium Azide), and a blood separator strip
  • 25 Malaria Whole Blood Wash Solution Dispensing Pipets
  • 25 Malaria Whole Blood Membrane Strips
  • 1 Ampoule Crusher
  • 25 Sample Transfer Pipets
  • 1 Procedure/Pictorial Guide
  • 1 Package Insert

Contact Akers Bio to learn how to purchase PIFA® Malaria Rapid Assay

Note: Product not approved for use within the U.S. except under military exemption.